Silicon Nanomembrane Tissue Chips to Aid Biomedical Researchers in Studying Barrier Cell Models
Two recent publications in the journal Advance Healthcare Materials feature SiMPore’s silicon nanomembranes in support of a modular and flexible tissue chip platform. Lead authors from the University of Rochester and the Rochester Institute of Technology called the modular platform the µSIM–a microfluidic device enabled by a silicon nanomembrane. The first publication by McCloskey et al describes the µSiM’s compatibility with barrier-forming cell culture and optical microscopy, while the second publication by Mansouri et al describes a plug-and-play module that can house and then apply flow to cultured cells within the µSiM. These developments are anticipated to address needs for improved tissue chip models that can reduce and replace animal experimentation, and someday, enable on-chip clinical trials.
The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro
McCloskey et al. | Advanced Healthcare Materials, 11, 2200804 (2022).
The Modular µSiM Reconfigured: Integration of Microfluidic Capabilities to Study In Vitro Barrier Tissue Models under Flow
Mansouri et al. | Advanced Healthcare Materials, 11, 2200802 (2022).