Authored by: Teagan Horan, Applications Scientist, SiMPore and Peng Miao, Applications Scientist, HORIBA Instruments Inc. Introduction USP788 is an accepted method by which to test parenteral drug products for the presence of subvisible particles 10 µm and larger. Method I utilizes light obscuration to detect and measure levels of these particles. When samples exceed the […]

SiMPore Inc. is replacing tolerance data in microns or nanometers with percentage of target diameter in its porous membrane chip products in order to match similar products on the market. Open Notice in new tab

At SiMPore, we provide the analytical tools for the consumer beverage industry to uncover answers and validate solutions when tackling the microplastics challenge in beverage products. SiMPore Filter Disks, comprising silicon nanomembrane technology feature precision-patterned, consistent pore geometry, enabling improved particle capture and analysis methodologies over other available filter options on the market. For this […]

As consumers become increasingly aware of the microplastic pollution problem, many are asking a critical question: does the pitcher filter on their kitchen counter actually protect them? Microplastic filtration — the process of physically removing microscopic plastic particles from water — has become a key consideration for health-conscious households. Yet until now, there has been […]

Choosing the right TEM window grid is an important step in achieving reliable, high-quality imaging. Researchers must often balance resolution, mechanical durability, and compatibility with existing instrumentation when making a selection. In this post, we outline the key factors to consider when selecting a TEM window grid and explain how each decision can impact performance […]

Have you ever looked at a glass of crystal-clear water and wondered what’s really in it? Beyond minerals, we now know it can contain thousands of microscopic plastic particles. They’re too small to see or taste, yet scientists can find them. The real question isn’t just if microplastics are present, but what kinds, how many, […]

SiMPore Inc. announces changes to the product numbers for its Filter Disk product family, effective November 11, 2025. Open Notice in new tab

SiMPore Inc. announces the change to a hexagonal chip shape for its Aperture Windows effective August, 2025. Open Notice in new tab

Introduction Many laboratories are newly interested in capturing and analyzing microplastics from a variety of samples, and need to acquire and set up the necessary apparatus to do so. This guide outlines the essentials for setting up and using SiMPore Filter Disks with the required filtration equipment. Using SiMPore Filter Disks Figure 1 below shows […]

SiMPore Inc. proudly announces the attainment of ISO 9001:2015 certification following the successful completion of an audit by DAC Audit Services LLC.

SiMPore Inc. announces the discontinuation of the µSiM-CV Barrier Cell Culture Kits and Related Components effective January 27, 2025.

The biological impact of microplastics in human food and water sources is largely unknown, and drinking water sources are not exempt from microplastic contamination. Here, we demonstrate a streamlined approach for capturing, quantifying, and identifying microplastics in drinking water. We present an analytical workflow termed Silicon Nanomembrane Analysis Pipeline (SNAP) that takes advantage of novel silicon nitride nanomembranes […]

Researchers at the University of Rochester are working on a method for rapid cancer diagnosis using SiMPore’s ultrathin nanomembranes. This technique, known as catch and display for liquid biopsies (CAD-LB), captures extracellular vesicles (EVs)—nano-sized carriers of cellular information—from minimally processed blood samples. By fluorescently labeling EVs caught in the membranes’ nanopores, CAD-LB enables quick detection […]

Extracellular vesicles (EVs) are lipid-bound particles shed by all cells. They are involved in cell-cell communication, but have recently gained significant interest for their potential use as diagnostics and as therapeutics. Researchers from multiple Universities recently published work demonstrating the capability of SiMPore’s Silicon Nanomembranes for catch-and-display of single EVs, enabling novel analyses of these nano-sized bio particles […]

The University of Rochester has received a $7.1 million contract from the Biomedical Advanced Research and Development Authority (BARDA) to develop innovative tissue-on-chip technology. This groundbreaking research aims to explore the link between respiratory diseases, such as influenza, and neurological symptoms like brain fog. The three-year project uses microphysiological systems (MPS)—tiny chips that simulate human […]

SiMPore Inc. announces the discontinuation of its nanoparticle separation vial products, effective August 16, 2024.

Introduction Analytical laboratories are constantly faced with balancing the costs and benefits of processing time,nconsumables cost, and the quality of collected data. When analyzing samples for microplastics, practitioners must consider laborious sample preparation, instrument data collection time, data analysis, and reporting time. This study compares two membranes – a commonly used 20 µm gold-coated polycarbonate […]

Check out what other researchers have done with SiMPore filters for microplastics capture and analysis.

Recent publications highlight the unique utility of SiMPore’s filters, which enable direct capture and analysis of microplastic particulates on the same filter without any burdensome transfers.

SiMPore supports the launch of the Lake Ontario Center for Microplastics and Human Health as they explore the effects of microplastics on the environment.

Technical Data Sheet: PDMS Sheets and Gaskets

Technical Data Sheet: Ultra-Thin Translucent PDMS Sheets Open the PDF in a new tab

James McGrath, SiMPore’s Co-Founder recently received a grant from NIH for University Research that could reduce the need for pharmaceutical trials on animals.

SiMPore was recently named a Top 10 Nano Material Solutions Provider and was featured in Manufacturing Technology Insights.

Instructions for Use Manual: Assembly of Flow Cells and Porous Membrane Chips

Instruction for Use: Handling and Cleaning Recommendations for Silicon-based TEM Window Grids

Instructions for Use Manual: Microplastics Filters

Researchers from SiMPore and the University of Rochester presented two posters, featuring nanomembrane-based analysis of single extracellular vesicles, at the 2023 ISEV annual meeting.

SiMPore researchers presented two posters at the recent Society of Environmental Toxicology and Chemistry North America 43rd Annual Meeting.

Two recent publications in the journal Advance Healthcare Materials feature SiMPore’s silicon nanomembranes in support of a modular and flexible tissue chip platform.

A poster created by SiMPore and Parverio related to joint work performed evaluating the filtration and imaging properties of filter membranes.

Product Information Sheet: Specifications and performance characteristics for Microslit Filters

Instructions for Use Manual: Assembly of Multiwell Plates and Porous Membrane Chips

Product Information Sheet: Specifications for single square, nine square, and two slot TEM Window Grids

Product Information Sheet: Differential pressure tolerance for TEM and X-Ray Window membranes by thickness and size